What Is Cannabinoid Hyperemesis Syndrome?

Cannabinoid hyperemesis syndrome as the name indicates is the condition in which excessive use of cannabis leads to repeated and severe vomiting. Hyperemesis is the term which describes severe vomiting. As emesis is the medical term used for vomiting. It is a rare condition and occurs due to long term excessive use of cannabis. Marijuana is another name of cannabis. Marijuana and some other Cannabinoids are usually used to treat vomiting and nausea, but if marijuana is administered for a long term at high concentration, then it may cause opposite effects. At high concentration, marijuana or cannabis can cause severe vomiting and nausea.

Cannabis is a plant from which marijuana and hashish is extracted. Marijuana is derived from flowers, dried leaves, seeds and stems of cannabis plant. Hashish is another drug derived from the concentrated resins of cannabis sativa female flower. There are several active substances in marijuana. The main ingredient is tetrahydrocannabinol THC and some related chemicals. These active chemicals of marijuana or cannabis has high affinity to cross blood brain barrier and bind to the receptors of brain. Due to it's affinity to bond with the receptors, it leads to high concentration of cannabis in brain. As a result it leads to Cannabinoid hyperemesis syndrome.

Not only brain, the gastrointestinal tract also has great affinity to bind with the molecules of cannabis. Cannabis effects the time of digestion of food and time of stomach emptying. It has a direct effect on esophageal sphincter. This sphincter is responsible for passing food from esophagus to stomach. So long term use of marijuana leads to the symptoms of cannabinoids hyperemesis syndrome CHS. It is an illegal drug which is widely used in the United States. Usually the adults are addicted to it. Rare of them develop cannabinoids hyperemesis syndrome because of extensive use of cannabis.

People who use cannabis at least once a day are more prone to cannabinoids hyperemesis syndrome. Vomiting and nausea are the symptoms of various medical problems, so diagnosis is an important part of treatment. There are no. Of tests which are performed to check the presence of cannabis in body. Following tests are performed.

Blood test, pregnancy test, electrolytes test, urine tests and most importantly drug screen. Cannabinoids hyperemesis syndrome is currently discovered, so many of the physicians doesn't know about it. There is another term "cyclical vomiting disorder", most of the health care providers mix cannabinoids hyperemesis syndrome with cyclical vomiting disorder. Because the main symptom i.e. vomiting is same in both cases.

It is a rare condition and still under study. Sometimes it proves fatal for the health of patient, if he doesn't consult with physician on time. Government has banned the use of cannabis or marijuana as it was becoming a major cause of death in adults. Cannabis is a strong drug. Once an adult got addicted to it, he cannot get rid of it easily. It directly effects brain and disturbs the physiological functioning of the whole body.

Cannabinoid Hyperemesis Syndrome Symptoms

Cannabinoid hyperemesis syndrome, as the name indicates is the increased and severe vomiting due to excessive use of cannabis. The main symptom of cannabinoids hyperemesis syndrome is repeated bouts of vomiting. In between 2 episodes of excessive or severe vomiting, there is a phase when patient experience no symptoms. This is called as asymptomatic phase. Physicians and other health care providers categorized cannabinoids hyperemesis syndrome in to three main stages. These stages are the phases i.e. prodromal phase, hyperemetic phase and the recovery phase. The symptoms are specified according to these main 3 phases.

1st of all prodromal phase, in this phase patient experience nausea and abdominal pain early morning almost every day. Sometimes patient feels like immediate vomiting. Due to these symptoms patient usually take care of his meal and change his eating pattern. Some of the patients start using marijuana, as they think marijuana will help them in getting rid of these symptoms specially nausea. Prodromal phase may last long from months to years.

The very next phase of cannabinoids hyperemesis syndrome is hyperemetic phase. The main symptoms of this phase include abdominal pain, repeated vomiting episodes, dehydration symptoms, continuous nausea, less food intake which leads to weight loss.

In this phase, vomiting does not stop and become worse. Vomiting is overwhelming and intense. People used to take a lot of hot showers during day as they think, taking bath will help them getting rid of nauseatic feeling. The physiology behind this is the hot water bath of hypothalamus part of brain. As hypothalamus is the part of brain which is responsible for controlling vomiting and thermoregulation. In this phase patient usually take medical care instead of home remedies.

Hyperemetic phase of cannabinoids hyperemesis syndrome may last long until patient stop taking marijuana completely. Once patient stop taking marijuana, the recovery phase starts right after that.
In recovery phase, the symptoms of cannabinoids hyperemesis syndrome start fading away. Patient feels good and no more nausea. The eating routine is back again. No more weight loss. Recovery phase may last from days to months. The time of recovery phase depends on the complete removal of marijuana from the life of patient.

All these symptoms of cannabinoids hyperemesis syndrome may come back if patient start taking cannabis or marijuana again. These drugs are not good for health. In most of the countries, marijuana and hashish are banned. As it's over use can lead to death. If vomiting does not stop, it may lead to the death of patient.

These symptoms may become severe if patient does not seek medical attention immediately. Different medications are prescribed to treat vomiting temporarily. As these medications are of no use untill or unless patient stop taking marijuana or cannabis completely.

These phases of cannabinoids hyperemesis syndrome have made it easy to understand the symptoms of cannabinoids hyperemesis syndrome. It has also helped to understand treatment plan accordingly to the phase of this syndrome. Sometimes its symptoms are mixed with the symptoms of many other diseases, so diagnosis is necessary.

Cannabinoid Hyperemesis Syndrome Causes

There are more than 400 different chemicals in the cannabis plant and almost 60 of them are cannabinoids. The pathophysiology of cannabinoids is simple but the other chemical components makes it difficult. These compounds have complex action through out the body. These chemicals show their effects in both gastrointestinal tract and central nervous system.

Increased intake of Marijuana is the main cause of cannabinoids hyperemesis syndrome. It imparts very complex effects on the body. Marijuana when effects brain, it imparts totally different effects of cannabinoids hyperemesis syndrome. It helps to treat or prevent vomiting and nausea. Marijuana is the useful drug which is used to stop nausea and vomiting and other symptoms in people having chemotherapy.

In case of digestive tract, marijuana has opposite effect. It may trigger nausea and vomiting in patients. Initially the use of marijuana Impart calming effect because the messages of Central nervous system are considered important than digestive tract messages. So marijuana Impart anti nausea effects initially. But if patient start taking drug regularly with increase in dose, then the receptors of brain cells become desensitized and stop responding to marijuana. So this is considered the main cause of severe and reapeated bouts of vomiting in people with cannabinoids hyperemesis syndrome.

There are two main theories which are proposed to understand the pathophysiology of cannabinoids hyperemesis syndrome. 1st one is cannabinoids buildup theory and 2nd one is hypothalamic theory.

Both of these therorie are based on the following concepts.

  • Buildup of cannabinoids in body due to increased dosing and toxicity. 
  • Functioning of the receptors of hypothalamus in brain regarding marijuana. 

The exact mechanism behind severe and uncontrollable vomiting is still unknown. Organic diseases are not considered as a possible cause for cannabinoids hyperemesis syndrome.

Cannabinoid Buildup Theory

The fat soluble cannabinoid is tetrahydrocannabinol THC that can easily find it's way to store in person's fat. As THC has long elimination half life. So whenever person feels stress and low energy, these stores of tetrahydrocannabinol THC start consuming themselves to produce energy for the body. That's how the already stored tetrahydrocannabinol THC start releasing. Tetrahydrocannabinol THC can then move toward the blood stream and as a result a high concentration of this cannabinoid can be diagnosed. This mechanism is also termed as "reintoxication effect". There is another cannabinoid named cannabigerol works by antagonizing the anti emeting effects.

Hypothalamic Theory

A Cannabinoid obtained from cannabis can increase the activity and functioning of cells of hypothalamus in brain. This Cannabinoid is named as cannabidiol. Along with this, tetrahydrocannabinol THC acts on a specific receptor of brain to produce hypothermic effect. It lowers the body temperature. So hot water bath helps a lot in reducing the symptoms of Cannabinoid

Hyperemesis Syndrome

This was all about the possible causes of Cannabinoid hyperemesis syndrome. The compounds of cannabis specially marijuana are responsible for causing this syndrome. At low dose, it feels refreshing but at high doses, it disturbs the whole system of hypothalamus and digestive tract leading to Cannabinoid hyperemesis syndrome.

Cannabinoid Hyperemesis Syndrome Treatment/Cure

As Cannabinoid hyperemesis syndrome occurs due to excessive intake of Cannabis, so quiting cannabis will help a lot in getting rid of this syndrome. The main symptoms of cannabinoid hyperemesis syndrome are nausea and vomiting. So various medications are prescribed but the effect is temporary. Traditional medications are useless in treating nausea and vomiting. When patient quit taking Cannabinoid, the symptoms take almost 7 to 10 days to relief. Patient education is an important part of Cannabinoid hyperemesis syndrome treatment, patient should have an idea that cannabis is making him/her ill.

Patient should know about the side effects of excessive Cannabinoid intake. The only treatment, which is considered effective till now, is quitting Cannabinoid intake. Cognitive behavioral therapy and motivational enhancement therapy are considered the treatment options for patients with Cannabinoid hyperemesis syndrome.

Patient usually take hot water bath to relief the symptoms. But it is temporarily. The temperature of water should be more than 41°C. Patient may experience dehydration due to excessive and severe vomiting and also due to hot water bath. This dehydration can be treated with the help of IV fluids. If patient face severe dehydration, then hospitalization is necessary. Patient should immediately quit taking Cannabinoid. Topical capsaicin is used by some of the clinicians just to relief the symptoms of cannabinoids hyperemesis syndrome. It is applied on the periumbilical area to treat the acute symptoms of cannabinoid hyperemesis syndrome.

Capsaicin has greater affinity and is effective in treating this syndrome. It is used as a 1st line treatment in Cannabinoid hyperemesis syndrome. In case, when capsaicin tube is not available, then hot water bath is preffered to stop vomiting and nausea immediately. But there are some precaution which should be kept in mind while preffering hot water bath. Patient should not have burn or injury on skin and patient should not be dehydrating.

It is not easy for patient to quit cannabis or marijuana immediately, it needs a psychological therapy to support the treatment mentally. So some of the antipsychotics are prescribed to to relief the symptoms completely. These antipsychotics are haloperidol and olanzapine. Sometimes benzodiazepines are also prescribed like lorazepam.

These show mixed results on patient. Other than these drugs, some of the other drugs are also prescribed but the efficacy of these drugs is not clear. So these drugs are under observation. These drugs include neurokinin 1 receptor antagonist, first generation anti histamines like diphenhydramine, non antipsychotic antidopaminergics like metoclopramide and 5 HT3 receptor antagonists.
Other than these all above mentioned drugs, acetaminophen is also considered of great benefit in treating

Cannabinoid hyperemesis syndrome. As it is helpful in treating the headache patient experience. Headache usually occurs due to increased stress on nervous system. Opioids are also used for the purpose of relieving abdominal pain. Patient due to severe vomiting, feels pain in stomach. This pain is usually unbearable. Opioids help a lot in treating pain. But opioids has a drawback of worsening nausea and vomiting so it's use is discouraged.

Cannabinoid Hyperemesis Syndrome Death Rate

Cannabinoid hyperemesis syndrome is a serious synrome. As excessive and intense vomiting leads to dehydration of patient. And severe dehydration may lead to death of the patient. As human body consist of 70% water and when patient experience excessive and intense vomiting, the water level become down. Less water level in body effects the functioning of body. As water contains various electrolytes and minerals in it.

These electrolytes and minerals are essential for the body to carry out various functions of the body. These electrolytes are essential for the cellular functions of the body. So when water level of the body gets down, the cellular functions of body cease or slow down. And ultimately leads to death of patient. In most of the cases, the excessive vomiting stopped immediately by taking hot water bath. As hot water bath relaxes hypothalamus of the brain and as a result patient get relief from nausea and vomiting.

Sometimes patient get faint at low water level in body and needs emergency treatment. IV fluids helps a lot in retrieving water level. It contains electrolytes and minerals which are essential for body. According to a research, almost 47.9 percent of people use cannabis or marijuana on daily basis. Some of the people use cannabis or marijuana more than one time per day. So the rough percentage estimate of those people is 23.7 percent. Some of the patients use it once a week. So the chances of

Cannabinoid hyperemesis syndrome are less in these patients. So people using cannabis once a week are 19.4 percent. As the administration frequency decreases, the chances of development of Cannabinoid hyperemesis syndrome also decreases. The chances are highest in patients who are taking Cannabinoid or marijuana frequently more than 1 time a day. And death rate is increasing due to these people.

Cannabinoid intake is kind of an addiction from which a patient cannot get rid of easily. There are only 2.4 percent users who are taking Cannabinoid or marijuana less frequently. So symptoms appear less frequently and are under control. There are greater chances of death in patients who are addicted of taking Cannabinoid more than one time a day. These patients experience recurrent episodes of excessive vomiting and nausea.

Patient may also experience abdominal and epigastric pain. These symptoms become severe if patient does not get treated on time. These episodes of severe vomiting and nausea may last up to 48 hours. In this time duration, the symptoms may become more severe and gradually become uncontrollable. Patient experience dehydration up to threatening level and ultimately leads to death. Along with severe dehydration, patient may also experience sudden weight loss.

The only solution of this Cannabinoid hyperemesis syndrome is to quit taking Cannabinoid immediately. People usually get afraid from the severity of symptoms and due to fear of death, they stop taking Cannabinoid anymore. It is not a common syndrome but it is grooming day by day. So patient education is necessary to control the death rate of Cannabinoid hyperemesis syndrome.

Cannabinoid Hyperemesis Syndrome 2016 Statistics

Cannabinoid hyperemesis syndrome which may also be known as cyclical vomiting disorder is highly associated with the excessive use of Cannabis. It was 1st discovered in the year 2000. Data from different sites on internet was gathered and analyzed. And then compiled on the basis of case reports and no. Of patients admitted due to Cannabinoid hyperemesis syndrome. Data was also extracted from the articles written on Cannabinoid hyperemesis syndrome. All of the data was combined in a commulative synthesis.

The data was based on the occurrence of Cannabinoid hyperemesis syndrome, diagnosis and the proposed treatment plans and then on the basis of survival and death rate. During data gathering almost 2178 articles were found regarding Cannabinoid hyperemesis syndrome, from which only 1253 were reviewed and 183 were selected for the data analysis. Data about the diagnosis of Cannabinoid hyperemesis syndrome include 14 articles. Along with this, the data main characteristics of this syndrome are mentioned below.

  • It is roughly estimated that almost 277 million people are taking Cannabinoid or marijuana i.e. 4.9 % of the total population. 
  • In 2014 to 2016 almost 22 million people were using cannabis or marijuana. In this calculation, which usually adults were involved. 
  • History of the Cannabis administration was taken in all cases of Cannabinoid hyperemesis syndrome. (100%) 
  • It was recorded that nausea and vomiting was seen as a main symptoms of Cannabinoid hyperemesis syndrome in all the cases. (100%)
  • On quiting cannbis or marijuana intake, almost 96.8 % of cases got treated. 
  • People got relief from symptoms by taking bath in almost 92.8 % of cases. 
  • Cannabinoid hyperemesis syndrome is recorded mainly in men as compare to women. As men are more in to addiction things as compare to women. So Cannabinoid hyperemesis syndrome was seen in men, in almost 72.9% of cases.
  • Abdominal pain was observed not in all the cases of Cannabinoid hyperemesis syndrome. The data collected on the basis of abdominal pain shows that, in almost 85.1% of patients abdominal pain was recorded. 
  • On the basis of cannabis or marijuana use, it is recorded that almost 97.4 % people use cannabis once a week. 

The mechanism of Cannabinoid hyperemesis syndrome was still unclear in 2016. So there were many treatment options proposed to treat this syndrome. Topical use of capsaicin was considered the best treatment for the acute Cannabinoid hyperemesis syndrome at that time. But it was temporary. The permanent treatment to this syndrome was quitting of cannabis or marijuana use. Talking about the differential diagnosis, Cannabinoid hyperemesis syndrome resembles a lot to cyclic vomiting disorder. As cyclical vomiting disorder is considered as a main symptom of Cannabinoid hyperemesis syndrome.

All the above mentioned data was recorded in the year 2016. As from year 2000 it was progressively increasing day by day. Now a days Cannabinoid use have become common among individuals and the death rate is also increasing day by day. Cannabinoid hyperemesis syndrome is still under investigation for the exact pathophysiology of this syndrome.

Cannabinoid Hyperemesis Syndrome 2017 Statistics

Cannabinoid hyperemesis syndrome is growing day by day. Initially when it was discovered, only a few people had knowledge about it. It is still under investigation for the exact pathology behind it. How Cannabinoid hyperemesis syndrome actually occur. This is the main question now a days and scientist are working on it. All the data recorded in 2016 is almost the same in 2017. The no. Of patients increased. Day by day the use of Cannabinoid is becoming a fashion. So adults find it adventurous to take Cannabinoid and be cool.

There is increase in number of people who are taking Cannabis or marijuana. Specially adults are reported with Cannabinoid hyperemesis syndrome.
Adults, usually the teenagers are suffering from this syndrome. Youth is becoming addict to marijuana or cannabis day by day. This is increasing the occurrence rate of Cannabinoid hyperemesis syndrome and ultimately the mortality and morbidity rate is also increasing.

The percentage of occurrence of Cannabinoid hyperemesis syndrome in men is the same as was in 2016. Because men are more prone to cannabinoid hyperemesis syndrome. Men usually take Cannabis and marijuana due to stress and to be cool in gatherings.

In 2017, the change was seen in the treatment plans. Physicians started using capsaicin topical formulation. It shows remarkable results in patients. Patient reported that he observed relief from symptoms after a few minutes of application of capsaicin topical formulation. Capsaicin topical cream ( 0.075%) was applied on a specific part of periumbilical area. This topical formulation acts locally on the desired site and effects by relieving the symptoms of Cannabinoid hyperemesis syndrome. It should be reapplied after every four hours. Patient reported that he felt burning sensation at the site of application and then gradually he felt improvement in the intense abdominal pain and nausea and vomiting.

It was considered the most effective treatment in 2017. But still it was temporary and require multiple dosage within a day. The permanent treatment of Cannabinoid hyperemesis syndrome was still the same i.e. quitting of Cannabinoid or marijuana permanently.

The death rate and disease rate of Cannabinoid hyperemesis syndrome is increasing. In 2016, a few deaths were reported but in 2017, the percentage of death rate increased. It is an abusive drug which got banned in most of the countries. The symptoms are specific in almost 90 percent of cases. The remaining 10 % of cases may have some other symptoms as well like abdominal pain, headache and bodyache.

All the statistical data recorded in 2016 got increase in percentage in 2017. For example if symptoms were reported in 96.8 percent of patients in 2016, then in 2017, it was reported in almost 98.5 percent of cases of Cannabinoid hyperemesis syndrome.

Likewise the death rate increased, the frequency of occurrence of Cannabinoid hyperemesis syndrome also increased, and a drastic change in the percentage of people suffering from Cannabinoid hyperemesis syndrome is seen. Due to ban on these drugs, it has been controlled a little bit but still its use is in fashion.

Cannabinoid Hyperemesis Syndrome 2018 Statistics

In 2018, the data about the prevalence of Cannabinoid hyperemesis syndrome was gathered. The data was specific about a place which was "urban public hospital". The data was all about the regular users of marijuana or cannabis. Usually patients of age 18 to 49 years, were admitted in the hospital emergency. The total number of patients admitted were 2127. And among them almost 155 patients were marijuana or cannabis regular users. It was estimated, according to the patients history, that these patients were using marijuana almost regularly i.e. 20 days a month.
A survey was conveyed on these patients by distributing a questionnaire among them. A trained researcher designed this questionnaire to collect data about the recovery methods and rate of recovery from Cannabinoid hyperemesis syndrome.

This questionnaire was of great use. In this survey, mostly patients with Cannabinoid hyperemesis syndrome survived by overcoming the severe and intense vomiting along with abdominal pain and nausea. They mentioned about taking hot water bath regularly and sometimes 3 to 4 times a day.
Patients resported that they experience the symptoms almost all the time. If they are smoking marijuana or cannabis, they are experiencing nausea and vomiting along with abdominal pain. All these symptoms does not appear off and on but all the time.

These patients rated hot water bath in such situation as the best way to get rid of these symptoms. They rated hot water bath on the scale of 1 to 10 which is 5 and sometimes 10. This is the easiest symptoms relief method. Patients who survived out of those, who were admitted in the hospital, almost 32 % were taking marijuana or Cannabis on regular basis. They met the criteria of having Cannabinoid hyperemesis syndrome.

In those patients the data gathered was all about Cannabinoid hyperemesis syndrome.
In those patients, history of cannabis or marijuana use was recorded with a specific duration of time.
Patients with Cannabinoid hyperemesis syndrome must experienced cyclic vomiting disorder in almost all the cases.

  • When these patients stopped taking cannabis or marijuana, they symptoms got resolved in almost 96.8% of cases. 
  • In 92 % of cases, the symptoms got relief by taking hot water bath. As it is considering the easiest way to get rid of these symptoms. 
  • Abdominal pain was not reported in all the cases like nausea and vomiting. In almost 82 % percent cases of Cannabinoid hyperemesis syndrome, the abdominal pain is reported. 
  • It was recorded that almost 92 % of users of cannabis or marijuana are using these abusive drugs on weekly basis to experience less symptoms. 
  • Mostly male patients were admitted to the hospital because males use cannabis or marijuana more commonly as compare to women. A survey report mentioned, almost 72 % of cases of Cannabinoid hyperemesis syndrome are about men. 
  • The symptoms of cannabinoids hyperemesis syndrome may last up to 24 to 48 hours. But it may last up to a week in some cases. It was concluded that, cessation of cannabis is the best and permanent treatment of Cannabinoid hyperemesis syndrome. 

Is Cannabinoid Hyperemesis Syndrome Real?

Cannabinoid hyperemesis syndrome is a condition occurs due to the excessive or abusive use of Cannabis or marijuana. This condition is not completely understood. Only chronic cannabis use can lead to Cannabinoid hyperemesis syndrome. Due to abusive use of cannabis or marijuana, patient experience excess and intense vomiting and nausea. It is most similar to the symptoms of pregnancy I.e. hyperemesis gravidarum. In this condition, pregnant lady experience morning sickness due to increased level of hormones.

Cannabis or marijuana is the abusive drug which is banned in most of the countries. As cannabis intake was increasing the morbidity rate and the death rate was also increasing. Usually men use Cannabis more commonly as compare to women. Depression and bad company compels to start using cannabis regularly but later on people got scared from the symptoms of Cannabinoid hyperemesis syndrome.

Marijuana is an abusive drug and it's long term use may lead to excessive vomiting, nausea and abdominal pain. All these symptoms are the associated with Cannabinoid hyperemesis syndrome.
It was 1st got under investigation in the year 2004. And in the current year, it's treatment was proposed. It was recorded that quitting cannabis or marijuana use totally can treat these symptoms permanently.

It is a real medical problem and curable. It's diagnosis make it real. Scientist properly designed a treatment protocol for the Cannabinoid hyperemesis syndrome. The symptoms of cannabinoids hyperemesis syndrome may last for several hours and then may resolve on it's own when patient does not smoke cannabis or marijuana later for few days.

  • It is a serious case, as long term vomiting leads to the excessive water loss from body. So body get dehydrated and leads to serious conditions like kidney failure. So the treatment is necessary. Usually people take hot water bath more than one time a day because it relief symptoms by relaxing the hypothalamus located in brain. 
  • Hypothalamus is the control center of vomiting. As hypothalamus get relaxed by taking hot water bath, the vomiting and nausea automatically relieved. When there is no more vomiting, there will be no more abdominal pain. 
  • Sometimes sudden quitting of Cannabis or marijuana may lead to severity of symptoms. But after some time, the symptoms got relief. 
  • When patient is admitted in to the hospital, intravenous fluids are administered to overcome the dehydration of patient. The intravenous fluids contain different nutrients which are necessary for the health of patient. 
  • Medications are also prescribed to relief symptoms. Like capsaicin topical cream is used to relax patient. It is applied on the periumbilical region and after some time patient experience relief in his symptoms. 
  • Other medications include anti emetics and pain killers. These all are the temporary treatment of Cannabinoid hyperemesis syndrome. The permanent treatment requires cessation of cannabis or marijuana. 
  • Apart from these treatment protocols, Cannabinoid hyperemesis syndrome is still a mystery. No one revealed the exact pathology behind Cannabinoid hyperemesis syndrome, that's why it is still a question " Is Cannabinoid hyperemesis syndrome real?" 

How Long Does Cannabinoid Hyperemesis Syndrome Last?

Cannabinoid hyperemesis syndrome only occurs when patient use cannabis or marijuana for longer time period. Its symptoms does not appear at the very 1st use of Cannabis or marijuana. Symptoms start appearing after prolong use of cannabis. Cannabinoid hyperemesis syndrome is all about the symptoms appearing as a result of abusive use of Cannabinoid. The single episode of cannabis use may lead to vomiting and nausea along with abdominal pain. And these symptoms may last up to 24 to 48 hours. These symptoms may reoccur if people start taking cannabis again. The interval between the appearance of next episode of symptoms may vary from few days to months.

These symptoms may subside permanently if patient stop taking marijuana or cannabis. There are three main phases of Cannabinoid hyperemesis syndrome. Each phase remains for a specific time. The 1st phase is prodromal phase. In this phase patient start experiencing symptoms and the symptoms are mild. Patient feel nausea and sometimes vomiting at morning time when he wakes up. It is also termed as morning sickness, which is usually experienced by pregnant women at the early stages of pregnancy. Sometimes patients try to get rid of these symptoms by taking more doses of marijuana or cannabis. But increased no. of doses leads to severity of symptoms. Hot water bath is an easiest and fastest way to get rid of these symptoms. So people instead of taking any more cannabis dose, prefer to take hot water bath. This initial phase of symptoms may last up to months or even years.

Moving on to the next phase, which is hyperemetic phase. In this phase, patient experience all the symptoms of Cannabinoid hyperemesis syndrome. These symptoms include retching, pain in abdomen, nausea and vomiting. The vomiting become severe and intense. Retching occurs more frequently i.e. up to 5 times per hour.

In this phase, the symptoms are on peak and require emergency treatment. Patient is not in a condition to take anything like food or medication through mouth. So it leads to sudden weight loss. Due to excessive vomiting, the water level of body gets down, this low level of water leads to dehydration of body. Dehydration may be horrendous and leads to severe medical conditions. Immediate IV fluids are required to inject. As IV fluids contain all the essential nutrients and vitamins and electrolytes to carry out normal functioning of body.

People who take shower more frequently, become addicted to it and excess hot water bath may also lead to dehydration. Usually patients with this phase of Cannabinoid hyperemesis syndrome are admitted to the emergency room of hospital for immediate treatment.

The 3rd or final phase of Cannabinoid hyperemesis syndrome is recovery phase. This phase only starts when patient stop taking marijuana or cannabis completely. This phase may last up to day to months. Everything got settled when patient stop taking marijuana. Patient does not have to take bath frequently because there are no more symptoms after quitting.

Is Cannabinoid Hyperemesis Syndrome Permanent?

Cannabinoid hyperemesis syndrome is a rare condition which is becoming common day by day due to increased use of cannabis in adults. Cannabis is an abusive drug which is banned in various countries but still people take Cannabinoids to be cool in friends or gatherings. Cannabinoid hyperemesis syndrome is still under investigation for the proper pathophysiology of this syndrome. So there is a question that "is Cannabinoid hyperemesis syndrome permanent?"

So here is the answer "No". Cannabinoid hyperemesis syndrome occurs due to increased or more frequent use of abusive drug marijuana or cannabis. So when people stop taking marijuana or cannabis, the symptoms disappear on it's own and Cannabinoid hyperemesis syndrome ends. Cannabinoid hyperemesis syndrome is all about the symptoms appearing due to cannabis or marijuana use. So when these symptoms subside, patient does not experience Cannabinoid hyperemesis syndrome anymore.

Sometimes cyclical vomiting disorder is mixed with Cannabinoid hyperemesis syndrome because of the symptoms. These two conditions have same symptoms but the conditions are different. Cannabinoid hyperemesis syndrome occurs due to cannabis use but cyclical vomiting disorder does not occur due to Cannabinoid use.

It is not permanent at all. When patient stop taking marijuana or cannabis, the symptoms start subsiding and Cannabinoid hyperemesis syndrome got treat. But this is not the end, if patient start using cannabis again, then these symptoms will start appearing again. It may take about days to months to subside the symptoms permanently.

The treatment is all dependant on the use of cannabis or marijuana. It is not easy to get rid of the addiction of cannabis or marijuana, so it takes some time. In this way, the Cannabinoid hyperemesis syndrome goes long term and more likely become permanent syndrome. In some cases, it takes years to resolve the symptoms. This makes people think "is Cannabinoid hyperemesis syndrome permanent?" . Prodromal phase is the longest phase of Cannabinoid hyperemesis syndrome, if patient continue on cannabis or marijuana on weekly basis.

  • As taking Cannabinoid on even weekly basis leads to mild symptoms of Cannabinoid hyperemesis syndrome. These mild symptoms have the tendency to last long until or u less patient stop taking marijuana or cannabis permanently. 
  • The elongated prodromal phase makes it look like permanent syndrome. But he fact is, it Is not permanent. By quitting abusive drug i.e. Cannabis or marijuana will treat Cannabinoid hyperemesis syndrome within a few days. 
  • Immediate quitting of Cannabis may 1st make the symptoms severe, but after 1 or 2 days, these symptoms start becoming mild and eventually fades away. 

Hyperemetic phase of Cannabinoid hyperemesis syndrome is the worse phase. In this phase patient require emergency treatment. And this phase should not last long , as it may lead to serious and complex problems and ultimately may cause death of patient. The morbidity and mortality rate of Cannabinoid hyperemesis syndrome is increasing due to less patient education. This is the clear concept of permanent Cannabinoid hyperemesis syndrome. It is a temporary condition which is still under investigation. It's getting common day by day.